Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium.

Journal article

The YjeQ class of P-loop GTPases assist in ribosome biogenesis and also bind to the 30S subunit of mature ribosomes. YjeQ ribosomal binding is GTP-dependent and thought to specifically direct protein synthesis, although the nature of the upstream signal causing this event in vivo is as yet unknown. The attenuating effect of YjeQ mutants on bacterial growth in Escherichia coli makes it a potential target for novel antimicrobial agents. In order to further explore the structure and function of ...

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Authors: Nichols, C; Johnson, C; Lamb, H; Lockyer, M; Charles, I

• Publication status: Published
• Journal: Acta crystallographica. Section F, Structural biology and crystallization communications
• Volume: 63
• Issue: Pt 11
• Pages: 922-928
• Publication date: 2007-11-01
• DOI: 10.1107/s1744309107048609
• EISSN: 1744-3091
• ISSN: 1744-3091
• Language: English
• Keywords: Amino Acid Sequence; Crystallization; Calorimetry; Sequence Alignment; Thermodynamics; GTP Phosphohydrolases; Salmonella typhimurium; Molecular Sequence Data; Crystallography, X-Ray