Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.

Journal article

The strength of T-cell receptor (TCR) stimulation and subsequent T-cell response depend on a combination of peptide-major histocompatibility complex (pMHC) density and potency. By comparing two different pMHC at doses yielding similar proliferation in vivo, we have highlighted unexpected differences in the qualitative and quantitative effects of TCR ligand. Measurements of cytokine sensitivity and two-photon imaging of T cell-dendritic cell (T-DC) interactions reveal discrimination between co...

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Authors: Gottschalk, R; Hathorn, M; Beuneu, H; Corse, E; Dustin, M

• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 109
• Issue: 3
• Pages: 881-886
• Publication date: 2012-01-01
• DOI: 10.1073/pnas.1119763109
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Interleukin-2; Dendritic Cells; Signal Transduction; Receptors, Antigen, T-Cell; Histocompatibility Antigens; Gene Expression Regulation; Mice; Male; Animals; Cell Proliferation; Receptors, Interleukin-2; Cell Communication; T-Lymphocytes; Peptides