Journal article
Smart superglue in streptococci? The proof is in the pulling
- Abstract:
- Gram-positive bacteria use reactive thioester-containing proteins to form covalent bonds, which may enable strong adhesion to host surfaces, but how these proteins selectively adhere to different surfaces is not clear. The Editors' Pick by Echelman et al. applied single-molecule force spectroscopy to show that an adhesin protein can regenerate its thioester in the absence of pulling. This selective interaction would represent a new principle of mechanical proof-reading, whereby only reactions supporting anchorage of the bacterium are maintained.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 179.7KB, Terms of use)
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- Publisher copy:
- 10.1074/jbc.H117.777466
Authors
- Publisher:
- American Society for Biochemistry and Molecular Biology
- Journal:
- Journal of Biological Chemistry More from this journal
- Volume:
- 292
- Issue:
- 21
- Pages:
- 8998-8999
- Publication date:
- 2017-05-26
- Acceptance date:
- 2017-04-14
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
- Language:
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English
- Pubs id:
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pubs:698074
- UUID:
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uuid:87868d83-62bd-4803-83e1-df62d58722f9
- Local pid:
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pubs:698074
- Source identifiers:
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698074
- Deposit date:
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2017-06-03
Terms of use
- Copyright holder:
- © 2017 by The American Society for Biochemistry and Molecular Biology, Inc
- Copyright date:
- 2017
- Notes:
- This is the publisher's version of the article. The final version is available online from American Society for Biochemistry and Molecular Biology at: 10.1074/jbc.H117.777466
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