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An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope.

Abstract:

The HLA-B27-restricted HIV gag cytotoxic T-lymphocyte (CTL) epitope, 265-279, is highly conserved amongst HIV-1 isolates, only one, HIV-1ELI, having a single amino acid substitution. Over the same region HIV-2 differs by five amino acids. As a broadly cross-protective AIDS vaccine should protect against infection from all isolates of HIV-1 and HIV-2, we tested CTL specific for the HIV-1 265-279 epitope with peptide analogues from HIV-1ELI, HIV-2 and two simian immunodeficiency virus (SIV) iso...

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Publication status:
Published

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Authors


Rothbard, J More by this author
Delchambre, M More by this author
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Journal:
AIDS (London, England)
Volume:
4
Issue:
9
Pages:
841-845
Publication date:
1990-09-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:877b31ba-cc35-4b51-9826-11ede3aa67f1
Source identifiers:
33617
Local pid:
pubs:33617

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