Journal article
APC/C(Cdh1) enables removal of Shugoshin-2 from the arms of bivalent chromosomes by moderating Cyclin-Dependent Kinase Activity.
- Abstract:
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In mammalian females, germ cells remain arrested as primordial follicles. Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of chromosomes, and their eventual alignment on metaphase plates. At the first meiotic division, anaphase-promoting complex/cyclosome associated with Cdc20 (APC/C(Cdc20)) activates separase and thereby destroys cohesion along chromosome arms. Because cohesion around centromeres is protected by shugoshin-2, sister chromatids remain attached thr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 6.2MB)
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- Publisher copy:
- 10.1016/j.cub.2017.04.023
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Novák, B
Grant:
BB/M00354X/1
+ Engineering and Physical Sciences Research Council
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Funding agency for:
Hopkins, M
Grant:
EP/G03706X/1
Boehringer Ingelheim Fonds
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Barbour Foundation
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+ Spanish Ministry of Economy, Industry and Competitiveness
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Grant:
BFU-2014-59307
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Current Biology Journal website
- Volume:
- 27
- Issue:
- 10
- Pages:
- 1462–1476.e5
- Publication date:
- 2017-05-01
- Acceptance date:
- 2017-04-12
- DOI:
- EISSN:
-
1879-0445
- ISSN:
-
0960-9822
- Source identifiers:
-
695769
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:695769
- UUID:
-
uuid:8768c91e-1d26-40bb-b801-edda06325fa7
- Local pid:
- pubs:695769
- Deposit date:
- 2017-05-24
Terms of use
- Copyright holder:
- Novak et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)
- Licence:
- CC Attribution (CC BY)
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