- Abstract:
-
In mammalian females, germ cells remain arrested as primordial follicles. Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of chromosomes, and their eventual alignment on metaphase plates. At the first meiotic division, anaphase-promoting complex/cyclosome associated with Cdc20 (APC/C(Cdc20)) activates separase and thereby destroys cohesion along chromosome arms. Because cohesion around centromeres is protected by shugoshin-2, sister chromatids remain attached thr...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 6.2MB)
-
- Publisher copy:
- 10.1016/j.cub.2017.04.023
-
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- Funding agency for:
- Hopkins, M
- Funding agency for:
- Novák, B
- Grant:
- BFU-2014-59307
- Publisher:
- Elsevier Publisher's website
- Journal:
- Current Biology Journal website
- Volume:
- 27
- Issue:
- 10
- Pages:
- 1462–1476.e5
- Publication date:
- 2017-05-05
- Acceptance date:
- 2017-04-12
- DOI:
- EISSN:
-
1879-0445
- ISSN:
-
0960-9822
- Pubs id:
-
pubs:695769
- URN:
-
uri:8768c91e-1d26-40bb-b801-edda06325fa7
- UUID:
-
uuid:8768c91e-1d26-40bb-b801-edda06325fa7
- Local pid:
- pubs:695769
- Language:
- English
- Keywords:
- Copyright holder:
- Novak et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)
Journal article
APC/C(Cdh1) enables removal of Shugoshin-2 from the arms of bivalent chromosomes by moderating Cyclin-Dependent Kinase Activity.
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+ Engineering and Physical Sciences Research Council
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+ Biotechnology and Biological Sciences Research Council
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Boehringer Ingelheim Fonds
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Barbour Foundation
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