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APC/C(Cdh1) enables removal of Shugoshin-2 from the arms of bivalent chromosomes by moderating Cyclin-Dependent Kinase Activity.

Abstract:

In mammalian females, germ cells remain arrested as primordial follicles. Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of chromosomes, and their eventual alignment on metaphase plates. At the first meiotic division, anaphase-promoting complex/cyclosome associated with Cdc20 (APC/C(Cdc20)) activates separase and thereby destroys cohesion along chromosome arms. Because cohesion around centromeres is protected by shugoshin-2, sister chromatids remain attached thr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cub.2017.04.023

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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Boehringer Ingelheim Fonds More from this funder
Barbour Foundation More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Current Biology Journal website
Volume:
27
Issue:
10
Pages:
1462–1476.e5
Publication date:
2017-05-05
Acceptance date:
2017-04-12
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Pubs id:
pubs:695769
URN:
uri:8768c91e-1d26-40bb-b801-edda06325fa7
UUID:
uuid:8768c91e-1d26-40bb-b801-edda06325fa7
Local pid:
pubs:695769

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