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Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation

Abstract:

The purpose of this exploratory study was to investigate the combination of a radiopharmaceutical, nanoparticles and ultrasound (US) enhanced delivery to develop a clinically viable therapeutic strategy for tumours overexpressing the epidermal growth factor receptor (EGFR). Molecularly targeted radionuclides have great potential for cancer therapy but are sometimes associated with insufficient delivery resulting in sub-cytotoxic amounts of radioactivity being delivered to the tumour. Liposome...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jconrel.2019.12.045

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Role:
Author
ORCID:
0000-0002-2094-9673
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Controlled Release Journal website
Volume:
319
Pages:
222-233
Publication date:
2019-12-28
Acceptance date:
2019-12-27
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
Source identifiers:
1080762
Language:
English
Keywords:
Pubs id:
pubs:1080762
UUID:
uuid:8764400c-27dc-4f3e-990a-d21dbeb0812b
Local pid:
pubs:1080762
Deposit date:
2020-01-03

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