Journal article
Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate
- Abstract:
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Purpose: To demonstrate the feasibility of mapping intracellular pH within the in vivo rodent heart. Introduction: Alterations in cardiac acid-base balance can lead to acute contractile depression and alterations in Ca2+ signalling. The transient reduction in ATP consumption and cardiac contractility may be initially beneficial; however, sustained pH changes can be maladaptive, leading to myocardial damage and electrical arrhythmias. Methods: Spectrally-selective RF pulses were used to excit...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 632.4KB)
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- Publisher copy:
- 10.1002/mrm.26260
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Funding
NIHR Oxford Biomedical Research Centre Programme
More from this funder
+ British Heart Foundation
More from this funder
Grant:
Fellowship (FS/10/002/28078, FS/14/17/30634)
Programme Grant (RG/11/9/28921
+ Engineering and Physical Sciences Research Council
More from this funder
Grant:
DoctoralTrainingCentre
PrizeFellowship(EP/M508111/1
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Magnetic Resonance in Medicine Journal website
- Publication date:
- 2016-05-15
- Acceptance date:
- 2016-04-06
- DOI:
- EISSN:
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1522-2594
- ISSN:
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0740-3194
- Source identifiers:
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614298
Item Description
- Keywords:
- Pubs id:
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pubs:614298
- UUID:
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uuid:875ebb65-d37e-4dc3-b37b-6e64d96ca23d
- Local pid:
- pubs:614298
- Deposit date:
- 2016-04-08
Terms of use
- Copyright holder:
- Lau et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Authors. Magnetic Resonance in Medicine published by WileyPeriodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License.
- Licence:
- CC Attribution (CC BY)
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