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Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate

Abstract:

Purpose: To demonstrate the feasibility of mapping intracellular pH within the in vivo rodent heart. Introduction: Alterations in cardiac acid-base balance can lead to acute contractile depression and alterations in Ca2+ signalling. The transient reduction in ATP consumption and cardiac contractility may be initially beneficial; however, sustained pH changes can be maladaptive, leading to myocardial damage and electrical arrhythmias. Methods: Spectrally-selective RF pulses were used to excit...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/mrm.26260

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy, and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy, and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy, and Genetics
Role:
Author

Contributors

Role:
Editor
NIHR Oxford Biomedical Research Centre Programme More from this funder
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Grant:
Fellowship (FS/10/002/28078, FS/14/17/30634); Programme Grant (RG/11/9/28921)
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Grant:
Doctoral Training Centre and Prize Fellowship (EP/M508111/1)
Publisher:
Wiley Publisher's website
Journal:
Magnetic Resonance in Medicine Journal website
Publication date:
2016-05-15
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
URN:
uuid:875ebb65-d37e-4dc3-b37b-6e64d96ca23d
Source identifiers:
614298
Local pid:
pubs:614298

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