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Thesis

Design of artificial metalloenzymes for C-C cross-coupling reactions

Abstract:

Artificial metalloenzymes enable several non-natural chemical transformations by hosting a metal catalyst and providing activating microenvironments to the metal. New strategies to combine the complementary features of enzyme and transition metal catalysis are crucial for exploiting the pre-evolved selectivities of enzymes in chemical synthesis. In order to exploit the inherent selectivity of a serine protease Subtilisin (SBL) for C-C crosscoupling reactions, the interplay of natural ...

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Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Department:
University of Oxford
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
ETH Zurich
Role:
Supervisor, Examiner
Department:
University of Oxford
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:8756ddda-60b7-45a6-9590-56eabf11f260
Deposit date:
2016-02-17

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