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Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.

Abstract:

To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a genome-wide association study of two case-control series, analyzing the genotypes with respect to 291,423 tagging SNPs in a total of 907 ALL cases and 2,398 controls. We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 x 10(-7)). The 10q21.2 ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.430

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Journal:
Nature genetics
Volume:
41
Issue:
9
Pages:
1006-1010
Publication date:
2009-09-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:872b1f9c-5214-499e-8a22-4d301701e344
Source identifiers:
72279
Local pid:
pubs:72279

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