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Molecular simulations of glycolipids: Towards mammalian cell membrane models

Abstract:

Glycolipids are key components of mammalian cell membranes, influencing a diverse range of cellular functions. For example, a number of receptor tyrosine kinases, including the epidermal growth factor receptor (EGFR), are allosterically regulated by the glycolipid monosialodihexosylganglioside (GM3). Recent advances in molecular dynamics methods, especially the development of coarse-grained models, have enabled simulations of increasingly complex models of cell membranes. We demonstrate these...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.biochi.2015.09.033

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Biochimie Journal website
Volume:
120
Pages:
105-109
Publication date:
2015-09-30
DOI:
ISSN:
0300-9084
Source identifiers:
571492
Keywords:
Pubs id:
pubs:571492
UUID:
uuid:870e9bf0-f812-41f8-b155-1cf079243fa8
Local pid:
pubs:571492
Deposit date:
2015-10-28

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