- Abstract:
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Glycolipids are key components of mammalian cell membranes, influencing a diverse range of cellular functions. For example, a number of receptor tyrosine kinases, including the epidermal growth factor receptor (EGFR), are allosterically regulated by the glycolipid monosialodihexosylganglioside (GM3). Recent advances in molecular dynamics methods, especially the development of coarse-grained models, have enabled simulations of increasingly complex models of cell membranes. We demonstrate these...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.4MB)
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- Publisher copy:
- 10.1016/j.biochi.2015.09.033
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- Funding agency for:
- Shorthouse, D
- Funding agency for:
- Hedger, G
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biochimie Journal website
- Volume:
- 120
- Pages:
- 105-109
- Publication date:
- 2015-09-30
- DOI:
- ISSN:
-
0300-9084
- URN:
-
uuid:870e9bf0-f812-41f8-b155-1cf079243fa8
- Source identifiers:
-
571492
- Local pid:
- pubs:571492
- Keywords:
- Copyright holder:
- Shorthouse et al.
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Molecular simulations of glycolipids: Towards mammalian cell membrane models
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+ Biotechnology and Biological Sciences Research Council
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+ Department of Biochemistry, University of
Oxford
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