- Abstract:
-
An efficient mode of HIV-1 infection of CD4 lymphocytes occurs in the context of infectious synapses, where dendritic cells (DCs) enhance HIV-1 transmission to lymphocytes. Emergence of CXCR4-using (X4) HIV-1 strains occurs late in the course of HIV-1 infection, suggesting that a selective pressure suppresses the switch from CCR5 (R5) to X4 tropism. We postulated that SDF-1/CXCL12 chemokine production by DCs could be involved in this process. We observed CXCL12 expression by DCs in vivo in th...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.02449-09
-
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- Journal:
- Journal of virology
- Volume:
- 84
- Issue:
- 9
- Pages:
- 4341-4351
- Publication date:
- 2010-05-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:86dfac5a-5188-4f3a-a3f1-c351b7527171
- Source identifiers:
-
48912
- Local pid:
- pubs:48912
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse.
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