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SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse.

Abstract:

An efficient mode of HIV-1 infection of CD4 lymphocytes occurs in the context of infectious synapses, where dendritic cells (DCs) enhance HIV-1 transmission to lymphocytes. Emergence of CXCR4-using (X4) HIV-1 strains occurs late in the course of HIV-1 infection, suggesting that a selective pressure suppresses the switch from CCR5 (R5) to X4 tropism. We postulated that SDF-1/CXCL12 chemokine production by DCs could be involved in this process. We observed CXCL12 expression by DCs in vivo in th...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02449-09

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Journal:
Journal of virology
Volume:
84
Issue:
9
Pages:
4341-4351
Publication date:
2010-05-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:86dfac5a-5188-4f3a-a3f1-c351b7527171
Source identifiers:
48912
Local pid:
pubs:48912

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