Journal article : Review
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
- Abstract:
- Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 682.4KB, Terms of use)
-
- Publisher copy:
- 10.1038/s41591-023-02502-5
Authors
+ European Union
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- Funder identifier:
- https://ror.org/019w4f821
- Grant:
- H2020-JTI-lMl2-2015-05
- Programme:
- agreement number 115974 - BEAt-DKD
+ Doris Duke Charitable Foundation
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- Funder identifier:
- https://ror.org/04n65rp89
- Grant:
- 2021258
- Programme:
- COVID-19 Fund to Retain Clinical Scientists collaborative grant program
+ Diabetes UK
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- Funder identifier:
- https://ror.org/050rgn017
- Grant:
- 21/0006277
- Programme:
- Sir George Alberti fellowship
+ National Health and Medical Research Council
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- Funder identifier:
- https://ror.org/011kf5r70
- Grant:
- 2000905
- Programme:
- Ideas Grant
+ National Institute of General Medical Sciences
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- Funder identifier:
- https://ror.org/04q48ey07
- Grant:
- T32GM774844
- Publisher:
- Springer Nature
- Journal:
- Nature Medicine More from this journal
- Volume:
- 29
- Issue:
- 10
- Pages:
- 2438-2457
- Place of publication:
- United States
- Publication date:
- 2023-10-05
- Acceptance date:
- 2023-07-14
- DOI:
- EISSN:
-
1546-170X
- ISSN:
-
1078-8956
- Pmid:
-
37794253
- Language:
-
English
- Subtype:
-
Review
- Pubs id:
-
1541403
- Local pid:
-
pubs:1541403
- Source identifiers:
-
W4387328184
- Deposit date:
-
2026-04-02
- ARK identifier:
Terms of use
- Copyright holder:
- Tobias et al.
- Copyright date:
- 2023
- Rights statement:
- © The Author(s), under exclusive licence to Springer Nature America, Inc. 2023
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