Journal article
Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation
- Abstract:
- Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson’s disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS). While beta fluctuations in PD patients are well characterized on shorter timescales, it is not known how beta activity evolves around the diurnal cycle, outside a clinical setting. Here, we obtained chronic recordings (34 ± 13 days) of subthalamic beta power in PD patients implanted with the Percept DBS device during high-frequency DBS and analysed their diurnal properties as well as sensitivity to artifacts. Time of day explained 41 ± 9% of the variance in beta power (p < 0.001 in all patients), with increased beta during the day and reduced beta at night. Certain movements affected LFP quality, which may have contributed to diurnal patterns in some patients. Future DBS algorithms may benefit from taking such diurnal and artifactual fluctuations in beta power into account.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 23.1MB, Terms of use)
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- Publisher copy:
- 10.1038/s41531-022-00350-7
Authors
- Publisher:
- Springer Nature
- Journal:
- npj Parkinson's Disease More from this journal
- Volume:
- 8
- Article number:
- 88
- Publication date:
- 2022-07-08
- Acceptance date:
- 2022-06-10
- DOI:
- EISSN:
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2373-8057
- Language:
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English
- Keywords:
- Pubs id:
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1262949
- Local pid:
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pubs:1262949
- Deposit date:
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2022-06-10
Terms of use
- Copyright holder:
- van Rheede et al.
- Copyright date:
- 2022
- Rights statement:
- © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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