Journal article
Gallery Game: Smartphone-based assessment of long-term memory in adults at risk of Alzheimer’s disease
- Abstract:
-
Introduction:
Gallery Game, deployed within the Mezurio smartphone app, targets the processes of episodic memory hypothesized to be first vulnerable to neurofibrillary tau-related degeneration in Alzheimer’s Disease, prioritizing both perirhinal and entorhinal cortex/hippocampal demands.
Methods:
Thirty-five healthy adults (aged 40–59 years), biased toward those at elevated familial risk of dementia, completed daily Gallery Game tasks for a month. Assessments consisted of cross-modal paired-associate learning, with subsequent tests of recognition and free recall following delays ranging from one to 13 days.
Results:
Retention intervals of at least three days were needed to evidence significant forgetting at both recognition and paired-associate recall test. The association between Gallery Game outcomes and established in-clinic memory assessments were small but numerically in the anticipated direction. In addition, there was preliminary support for utilizing the perirhinal-dependent pattern of semantic false alarms during object recognition as a marker of early impairment.
Conclusions:
These results support the need for tests of longer-term memory to sensitively record behavioral differences in adults with no diagnosis of cognitive impairment. Aggregate behavioral outcomes promote Gallery Game’s utility as a digital assessment of episodic memory, aligning with established theoretical models of object memory and showing small yet uniform associations with existing in-clinic tests. Initial support for the discriminatory value of perirhinal-targeted outcomes justifies ongoing large-sample validation against traditional biomarkers of Alzheimer’s disease.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, 646.3KB, Terms of use)
-
- Publisher copy:
- 10.1080/13803395.2020.1714551
Authors
- Publisher:
- Taylor and Francis
- Journal:
- Journal of Clinical and Experimental Neuropsychology More from this journal
- Volume:
- 42
- Issue:
- 4
- Pages:
- 329–343
- Publication date:
- 2020-01-24
- Acceptance date:
- 2019-12-26
- DOI:
- EISSN:
-
1744-411X
- ISSN:
-
1380-3395
- Pmid:
-
31973659
- Language:
-
English
- Keywords:
- Pubs id:
-
1083912
- Local pid:
-
pubs:1083912
- Deposit date:
-
2020-04-09
Terms of use
- Copyright holder:
- Informa UK Limited
- Copyright date:
- 2020
- Rights statement:
- © 2020 Informa UK Limited, trading as Taylor & Francis Group
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Taylor and Francis at: https://doi.org/10.1080/13803395.2020.1714551
If you are the owner of this record, you can report an update to it here: Report update to this record