Journal article

Enantioselective Synthesis of Sealutomicin C

Abstract:: The sealutomicins are a family of anthraquinone antibiotics featuring an enediyne (sealutomicin A) or Bergman-cyclized aromatic ring (sealutomicins B–D). Herein we report the development of an enantioselective organocatalytic method for the synthesis of dihydroquinolines and the use of the developed method in the total synthesis of sealutomicin C which features a transannular cyclization of an aryllithium onto a γ-lactone as a second key step.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Astle, S. M., Guggiari, S., Frost, J. R., Hepburn, H. B., Klauber, D. J., Christensen, K. E., & Burton, J. W. (2024). Enantioselective Synthesis of Sealutomicin C. Journal of the American Chemical Society, 146(26), 17757–17764.

MLA Style

Astle, S. M., et al. “Enantioselective Synthesis of Sealutomicin C.” Journal of the American Chemical Society, vol. 146, no. 26, American Chemical Society, 2024, pp. 17757–64.

Chicago Style

Astle, SM, S Guggiari, JR Frost, HB Hepburn, DJ Klauber, KE Christensen, and JW Burton. 2024. “Enantioselective Synthesis of Sealutomicin C.” Journal of the American Chemical Society 146 (26): 17757–64.
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Files:: Astle_et_al_2024_Enantioselective_Synthesis_of.pdf

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Publisher copy:: 10.1021/jacs.4c02969

Authors

+ Astle, SM More by this author

Institution:: University of Oxford
Division:: HUMS
Department:: Classics Faculty
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0009-0009-9123-4374

+ Guggiari, S More by this author

Institution:: University of Oxford
Division:: HUMS
Department:: Classics Faculty
Sub department:: Chemistry Research Laboratory
Role:: Author

+ Frost, JR More by this author

Role:: Author
ORCID:: 0000-0002-4966-0419

+ Hepburn, HB More by this author

Role:: Author

+ Klauber, DJ More by this author

Role:: Author
ORCID:: 0000-0003-1166-813X

More authors...

+ Takeda More from this funder

Funder identifier:: https://ror.org/04hjbmv12

+ Engineering and Physical Sciences Research Council More from this funder

Funder identifier:: https://ror.org/0439y7842

+ Diamond Light Source More from this funder

Funder identifier:: https://ror.org/05etxs293

+ Defence Science and Technology Laboratory More from this funder

Funder identifier:: https://ror.org/04jswqb94

Publisher:: American Chemical Society
Journal:: Journal of the American Chemical Society More from this journal
Volume:: 146
Issue:: 26
Pages:: 17757-17764
Publication date:: 2024-06-17
Acceptance date:: 2024-05-07
DOI:: 10.1021/jacs.4c02969
EISSN:: 1520-5126
ISSN:: 0002-7863

Language:: English
Source identifiers:: 2165320
Deposit date:: 2024-08-06

Terms of use

Copyright date:: 2024

Licence:: CC Attribution (CC BY)

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