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Journal article

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.

Abstract:

DNA polymerase eta is a Y family polymerase involved in translesion synthesis (TLS). Its action is initiated by simultaneous interaction between the PIP box in pol eta and PCNA and between the UBZ in pol eta and monoubiquitin attached to PCNA. Whereas monoubiquitination of PCNA is required for its interaction with pol eta during TLS, we now show that monoubiquitination of pol eta inhibits this interaction, preventing its functions in undamaged cells. Identification of monoubiquitination sites...

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Publication status:
Published

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Authors


Sabbioneda, S More by this author
Crosetto, N More by this author
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Journal:
Molecular cell
Volume:
37
Issue:
3
Pages:
396-407
Publication date:
2010-02-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:8665806a-1be1-4166-a48d-3f1861ec746c
Source identifiers:
365417
Local pid:
pubs:365417

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