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Interferon lambdas: the next cytokine storm

Abstract:

For two decades the scientific community has sought to understnad why some people clear hepatitis C virus (HCV) and others do not. Recently, several large genome-wide association studies have identified single nucleotide polymorphisms (SNPs) linked to interferon lambda 3 (IFNλ3) that are associated with the spontaneous resolution and successful treatment of HCV infection. These observations are generating intense research activity; the hope is that IFNλ3 genetic variants may serve as importan...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/gut.2010.222976

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Gut Journal website
Volume:
60
Issue:
9
Pages:
1284-1293
Publication date:
2011
DOI:
EISSN:
1468-3288
URN:
uuid:86558d88-2334-4d13-b8e0-9f97d5bc90b2
Local pid:
ora:5939

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