Journal article
GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels
- Abstract:
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Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon‐like peptide‐1 (GLP‐1) is released from the gut and is used in T2DM therapy. Uniquely, it both stimulates insulin and inhibits glucagon secretion and thereby lowers plasma glucose levels. In this study, we have investigated the action of GLP‐1 on glucagon release from human pancreatic islets. Immunocytochemistry revealed that only <0.5% of t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 769.8KB)
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- Publisher copy:
- 10.14814/phy2.13852
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Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Physiological Reports Journal website
- Volume:
- 6
- Issue:
- 17
- Article number:
- e13852
- Publication date:
- 2018-09-05
- Acceptance date:
- 2018-08-07
- DOI:
- ISSN:
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2051-817X
Item Description
- Keywords:
- Pubs id:
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pubs:905542
- UUID:
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uuid:85d072ec-8e53-4c26-8371-e01f50580a22
- Local pid:
- pubs:905542
- Deposit date:
- 2018-08-13
Terms of use
- Copyright holder:
- 2018 Ramracheya, et al
- Copyright date:
- 2018
- Notes:
-
© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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