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GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels

Abstract:

Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon‐like peptide‐1 (GLP‐1) is released from the gut and is used in T2DM therapy. Uniquely, it both stimulates insulin and inhibits glucagon secretion and thereby lowers plasma glucose levels. In this study, we have investigated the action of GLP‐1 on glucagon release from human pancreatic islets. Immunocytochemistry revealed that only <0.5% of t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.14814/phy2.13852

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Role:
Author
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Funding agency for:
Ramracheya, R
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Funding agency for:
Ramracheya, R
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Funding agency for:
Zhang, Q
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Funding agency for:
Briant, L
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Publisher:
Wiley Publisher's website
Journal:
Physiological Reports Journal website
Volume:
6
Issue:
17
Pages:
Article: e13852
Publication date:
2018-09-05
Acceptance date:
2018-08-07
DOI:
ISSN:
2051-817X
Pubs id:
pubs:905542
URN:
uri:85d072ec-8e53-4c26-8371-e01f50580a22
UUID:
uuid:85d072ec-8e53-4c26-8371-e01f50580a22
Local pid:
pubs:905542

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