Journal article
Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study
- Abstract:
- Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index case. Median ages of groups (infected; 10.0 years, uninfected 8.8 years) were not significantly different (p = 0.13). Mean vitamin D levels were 2.05 ng/mL (95% CI - 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance. Conclusion: Vitamin D levels were higher in TB-uninfected children compared with TB-infected despite equal high exposure to a TB case.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.0MB, Terms of use)
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- Publisher copy:
- 10.1007/s00431-021-04272-z
Authors
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MC_EX_MR/K011944/1
- MR/K023446/1
+ Academy of Medical Sciences
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- Funder identifier:
- https://ror.org/00c489v88
- Grant:
- SGL019\1045
- Publisher:
- Springer Nature
- Journal:
- European Journal of Pediatrics More from this journal
- Volume:
- 181
- Issue:
- 3
- Pages:
- 1263-1267
- Place of publication:
- Germany
- Publication date:
- 2021-10-13
- Acceptance date:
- 2021-09-22
- DOI:
- EISSN:
-
1432-1076
- ISSN:
-
0340-6199
- Pmid:
-
34643785
- Language:
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English
- Keywords:
- Pubs id:
-
1205684
- Local pid:
-
pubs:1205684
- Deposit date:
-
2024-12-17
- ARK identifier:
Terms of use
- Copyright holder:
- Stockdale et al
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Author. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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