Journal article

Synthesis of the Spirotetracyclic Core of the Ginkgolides via a Malonyl Radical Cascade

Abstract:: The ginkgolides are a family of terpene trilactone natural products exclusive to the Ginkgo biloba tree. Here, we present a concise synthesis of their spirotetracyclic core via a manganese(III)-mediated oxidative radical cascade. Beginning from six simple starting materials, this route enables the diastereoselective synthesis of rings A, B, D and E of the natural product in nine steps, laying the foundations for their total synthesis.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Hernández-Lladó P, Christensen, K. E., & Burton, J. W. (2025). Synthesis of the Spirotetracyclic Core of the Ginkgolides via a Malonyl Radical Cascade. Organic Letters, 27(29), 7927–7932.

MLA Style

Hernández-Lladó P, et al. “Synthesis of the Spirotetracyclic Core of the Ginkgolides via a Malonyl Radical Cascade.” Organic Letters, vol. 27, no. 29, American Chemical Society, 2025, pp. 7927–32.

Chicago Style

Hernández-Lladó P, KE Christensen, and JW Burton. 2025. “Synthesis of the Spirotetracyclic Core of the Ginkgolides via a Malonyl Radical Cascade.” Organic Letters 27 (29): 7927–32.
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Files:: Hernandez-Llado_et_al_2025_Synthesis_of_the.pdf

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Publisher copy:: 10.1021/acs.orglett.5c02247

Authors

+ Hernández-Lladó, P More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0000-0003-2465-3949

+ Christensen, KE More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author

+ Burton, JW More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0000-0002-5181-5301

+ Engineering and Physical Sciences Research Council More from this funder

Funder identifier:: https://ror.org/0439y7842

Publisher:: American Chemical Society
Journal:: Organic Letters More from this journal
Volume:: 27
Issue:: 29
Pages:: 7927-7932
Publication date:: 2025-07-14
Acceptance date:: 2025-07-07
DOI:: 10.1021/acs.orglett.5c02247
EISSN:: 1523-7052
ISSN:: 1523-7060

Language:: English
Source identifiers:: 3151240
Deposit date:: 2025-07-28

Terms of use

Copyright date:: 2025

Licence:: CC Attribution (CC BY)

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