Journal article
Cost-effectiveness of mechanical thrombectomy for treatment of non-minor ischaemic stroke across Europe
- Abstract:
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Background and Purpose:
Mechanical thrombectomy (MT) has been recommended for the treatment of nonminor ischemic stroke by national and international guidelines, but cost-effectiveness evidence has been generated for only a few countries using heterogeneous evaluation methods. We estimate the cost-effectiveness of MT across 32 European countries.
Methods:
A Markov model was developed to estimate the cost-effectiveness of MT compared with standard care over a 5-year time horizon. Patients with ischemic stroke eligible for MT were identified from 2017 country-specific incidence data. A societal perspective was adopted, including health, social, and informal care costs, and productivity losses. Model outcomes were expressed as quality-adjusted life years. Sensitivity analyses were conducted to test the robustness of findings.
Results:
We identified 267 514 ischemic stroke cases that were eligible for MT treatment across 32 European countries. MT was found to be more effective and cheaper than standard care in two-thirds of the countries (21/32) and cost-effective in all but one country (Bulgaria). Across Europe, the intervention was estimated to produce over 101 327 additional quality-adjusted life years (95% uncertainty interval, 65 180–149 085) and cost savings of $981 million (€868 million, 95% uncertainty interval, −1544 to 2564) and of $1.7 billion (€1.5 billion, 95% uncertainty interval, −1.2 to 3.6) in health and social care and societal costs, respectively.
Conclusions:
MT is highly likely to be cost-effective compared with standard care across Europe as a whole and in the vast majority of European countries.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 777.5KB, Terms of use)
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- Publisher copy:
- 10.1161/STROKEAHA.120.031027
Authors
- Publisher:
- American Heart Association
- Journal:
- Stroke More from this journal
- Volume:
- 52
- Issue:
- 2
- Pages:
- 664-673
- Publication date:
- 2021-01-11
- Acceptance date:
- 2020-11-07
- DOI:
- EISSN:
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1524-4628
- ISSN:
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0039-2499
- Language:
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English
- Keywords:
- Pubs id:
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1148240
- Local pid:
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pubs:1148240
- Deposit date:
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2020-12-08
- ARK identifier:
Terms of use
- Copyright holder:
- Candio et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
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