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Journal article

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

Abstract:

Murine T-helper clones are classified into two distinct subsets (Th1 and Th2) on the basis of their patterns of lymphokine secretion. Th1 clones secrete interleukin-2 (IL-2), tumour necrosis factor-beta (TNF-beta) and interferon-gamma (IFN-gamma), whereas Th2 clones secrete IL-4, IL-5 and IL-10 (ref. 1). These subsets are reciprocally regulated by IL-4, IL-10 and IFN-gamma and differentially promote antibody or delayed-type hypersensitivity responses. To evaluate whether IL-4 is required for ...

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Publication status:
Published

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Publisher copy:
10.1038/362245a0

Authors


Le Gros, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Lamers, MC More by this author
Bluethmann, H More by this author
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Journal:
Nature
Volume:
362
Issue:
6417
Pages:
245-248
Publication date:
1993-03-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:854e30eb-d5aa-47ad-8fc4-451643e2135d
Source identifiers:
469279
Local pid:
pubs:469279

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