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Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure.

Abstract:

BACKGROUND: Elevated plasma norepinephrine levels are associated with increased mortality in patients and in animal models with chronic heart failure. To test which alpha2-adrenoceptor subtypes operate as presynaptic inhibitory receptors to control norepinephrine release in heart failure, we investigated the response of gene-targeted mice lacking alpha2-adrenoceptor subtypes (alpha2-KO) to chronic left ventricular pressure overload. In addition, we determined the functional consequences of g...

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Publication status:
Published

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Journal:
Circulation
Volume:
106
Issue:
19
Pages:
2491-2496
Publication date:
2002-11-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
124682
Language:
English
Keywords:
Pubs id:
pubs:124682
UUID:
uuid:8548d481-c40a-4d7f-a424-e559b8eb1b0b
Local pid:
pubs:124682
Deposit date:
2012-12-19

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