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Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei.

Abstract:

Transmission of malaria parasites from vertebrate blood to the mosquito vector depends critically on the differentiation of the gametocytes into gametes. This occurs in response to environmental stimuli encountered by the parasite in the mosquito bloodmeal. Male gametogenesis involves three rounds of DNA replication and endomitosis, and the assembly de novo of 8 motile axonemes. Azadirachtin, a plant limnoid and insecticide with an unkown mode of action, specifically inhibits the release of m...

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Authors


Billker, O More by this author
Mordue, AJ More by this author
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Journal:
The Journal of eukaryotic microbiology
Volume:
49
Issue:
6
Pages:
489-497
Publication date:
2002
DOI:
EISSN:
1550-7408
ISSN:
1066-5234
URN:
uuid:8539bfe6-b529-4194-9c22-a623bb5a1e8a
Source identifiers:
257427
Local pid:
pubs:257427

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