Journal article
Redox capacitive assaying of C-reactive protein at a peptide supported aptamer interface
- Abstract:
- Electrochemical immunosensors offer much in the potential translation of a lab based sensing capability to a useful "real world" platform. In previous work we have introduced an impedance-derived electrochemical capacitance spectroscopic analysis as supportive of a reagentless means of reporting on analyte target capture at suitably prepared mixed-component redox-active, antibody-modified interfaces. Herein we directly integrate receptive aptamers into a redox charging peptide support in enabling a label-free low picomolar analytical assay for C-reactive protein with a sensitivity that significantly exceeds that attainable with an analogous antibody interface.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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-
(Preview, Accepted manuscript, pdf, 672.6KB, Terms of use)
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- Publisher copy:
- 10.1021/acs.analchem.7b05374
Authors
- Publisher:
- American Chemical Society
- Journal:
- Analytical Chemistry More from this journal
- Volume:
- 90
- Issue:
- 5
- Pages:
- 3005-3008
- Publication date:
- 2018-02-07
- Acceptance date:
- 2018-02-07
- DOI:
- EISSN:
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1520-6882
- ISSN:
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0003-2700
- Pmid:
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29411973
- Language:
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English
- Keywords:
- Pubs id:
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pubs:823210
- UUID:
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uuid:85310d20-752c-4ccb-8fad-fb2b9b44fa6a
- Local pid:
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pubs:823210
- Source identifiers:
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823210
- Deposit date:
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2018-04-04
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Chemical Society. This is the accepted manuscript] version of the article. The final version is available online from the American Chemical Society at: 10.1021/acs.analchem.7b05374
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