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Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1

Abstract:

Trafficking of tissue dendritic cells (DCs) via lymph is critical for the generation of cellular immune responses in draining lymph nodes (LNs). In the current study we found that DCs docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1, in dynamic transmigratory-cup-like structures. Furthermore, we show that targeted deletion of the gene Lyve1, antibody blockade or deplet...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ni.3750

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Immunology Journal website
Volume:
18
Pages:
762-770
Publication date:
2017-05-15
Acceptance date:
2017-04-24
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pubs id:
pubs:695429
URN:
uri:852aca16-5dcb-4392-92e9-43284da52c9a
UUID:
uuid:852aca16-5dcb-4392-92e9-43284da52c9a
Local pid:
pubs:695429

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