Journal article
A critical balance: dNTPs and the maintenance of genome stability
- Abstract:
- A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a physiologically normal range. The importance of understanding these consequences is relevant to genetic disorders that disturb dNTP levels, and strategies that inhibit dNTP synthesis in cancer chemotherapy and for treatment of other disorders. We review here how abnormal dNTP levels affect DNA replication and discuss the consequences for genome stability.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 723.3KB, Terms of use)
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- Publisher copy:
- 10.3390/genes8020057
Authors
- Publisher:
- MDPI
- Journal:
- Genes More from this journal
- Volume:
- 8
- Issue:
- 2
- Pages:
- 57-57
- Publication date:
- 2017-02-01
- Acceptance date:
- 2017-01-24
- DOI:
- ISSN:
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2073-4425
- Keywords:
- Pubs id:
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pubs:677365
- UUID:
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uuid:84df7d17-8910-4e67-93a9-45b2f6b153a7
- Local pid:
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pubs:677365
- Source identifiers:
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677365
- Deposit date:
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2017-02-08
- ARK identifier:
Terms of use
- Copyright holder:
- Pai and Kearsey
- Copyright date:
- 2017
- Notes:
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Copyright © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons by
Attribution (CC‐BY) license (http://creativecommons.org/licenses/by/4.0/).
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