Cytolytically active murine T-cell hybrids.

Journal article

Following the demonstration that hybrids between normal B-lymphocytes and myeloma cell lines continue to secrete antibodies with the same specificity as those produced by the parental B-cells, many groups have tried to use this approach to obtain cell lines expressing T-lymphocyte functions by crossing thymoma lines not expressing any measurable activity with various types of T-cell populations. Although there have been reports that hybrids could be isolated which secrete T-cell products with...

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Authors: Nabholz, M; Cianfriglia, M; Acuto, O; Conzelmann, A; Haas, W

• Publication status: Published
• Journal: Nature
• Volume: 287
• Issue: 5781
• Pages: 437-440
• Publication date: 1980-10-01
• DOI: 10.1038/287437a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Hybrid Cells; Cytotoxicity, Immunologic; Growth Substances; H-2 Antigens; T-Lymphocytes; Mice; Animals; Cell Division; Concanavalin A