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Maternal circulating levels of syncytiotrophoblast vesicles expressing Dipeptidyl Peptidase IV (DPPIV) are increased in Gestational Diabetes Mellitus

Abstract:: Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder of pregnancy. Plasma of women with GDM display lower levels of glucagon-like peptide-1 (GLP-1), which increases insulin secretion and thus regulates glucose homeostasis. GLP-1 concentration normalizes after delivery; suggesting placental involvement in regulating maternal glucose-dependent insulin secretion. The syncytiotrophoblast of the human placenta produces and secretes extracellular vesicles (STBEVs) into the maternal circulation, by which the placenta may affect maternal metabolism. We analysed the presence of dipeptidyl peptidase IV (DPPIV), a potent inhibitor of GLP-1, on STBEVs in GDM and normal pregnancy

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Kandzija, N., Zhang, W., Mejia, C., Mhlomi, V., McGowan-Downey, J., Cerdeira, A., Tannetta, D., Sargent, I., Redman, C., Vatish, M., & Bastie, C. (2018). Maternal circulating levels of syncytiotrophoblast vesicles expressing Dipeptidyl Peptidase IV (DPPIV) are increased in Gestational Diabetes Mellitus. 69, E7.

MLA Style

Kandzija, N, et al. “Maternal Circulating Levels of Syncytiotrophoblast Vesicles Expressing Dipeptidyl Peptidase IV (DPPIV) Are Increased in Gestational Diabetes Mellitus.” vol. 69, 2018, p. E7.

Chicago Style

Kandzija, N, W Zhang, C Mejia, et al. 2018. “Maternal Circulating Levels of Syncytiotrophoblast Vesicles Expressing Dipeptidyl Peptidase IV (DPPIV) Are Increased in Gestational Diabetes Mellitus.” 69: E7.
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Publisher copy:: 10.1016/j.placenta.2018.06.005

Authors

+ Kandzija, N More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Women's & Reproductive Health
Role:: Author

+ Zhang, W More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Women's & Reproductive Health
Role:: Author

+ Mejia, C More by this author

Role:: Author

+ Mhlomi, V More by this author

Institution:: University of Oxford
Division:: Social Sciences Division
Department:: Said Business School
Role:: Author

+ McGowan-Downey, J More by this author

Role:: Author

More authors...

Publisher:: Elsevier
Host title:: Placenta
Journal:: 2018 International Federation of Placenta Associations Meeting (IFPA 2018) More from this journal
Volume:: 69
Pages:: E7
Publication date:: 2018-09-10
DOI:: 10.1016/j.placenta.2018.06.005
EISSN:: 1532-3102
ISSN:: 0143-4004

Pubs id:: pubs:921715
UUID:: uuid:84b99b07-03ae-41f8-a3fc-6545b0b487cc
Local pid:: pubs:921715
Source identifiers:: 921715
Deposit date:: 2018-10-02
ARK identifier:: ark:/29072/ora_84b99b0703ae41f8a3fc6545b0b487cc

Terms of use

Copyright holder:: Elsevier Ltd
Copyright date:: 2018
Notes:: Copyright © 2018 Elsevier Ltd. All rights reserved. This abstract was presented at the 2018 International Federation of Placenta Associations Meeting (IFPA 2018)

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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