The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase.

Journal article

Bacterial resistance to antibiotics usually incurs a fitness cost in the absence of selecting drugs, and this cost of resistance plays a key role in the spread of antibiotic resistance in pathogen populations. Costs of resistance have been shown to vary with environmental conditions, but the causes of this variability remain obscure. In this article, we show that the average cost of rifampicin resistance in the pathogenic bacterium Pseudomonas aeruginosa is reduced by the addition of ribosome...

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Authors: Hall, A; Iles, J; Maclean, C

• Publication status: Published
• Journal: Genetics
• Volume: 187
• Issue: 3
• Pages: 817-822
• Publication date: 2011-03-01
• DOI: 10.1534/genetics.110.124628
• EISSN: 1943-2631
• ISSN: 0016-6731
• Language: English
• Keywords: DNA Gyrase; Genetic Fitness; Rifampin; DNA-Directed RNA Polymerases; Penicillin-Binding Proteins; Mutation; Drug Resistance, Bacterial; Pseudomonas aeruginosa; Anti-Bacterial Agents