Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice.

Journal article

Stimulation of nitric oxide (NO) release from the coronary endothelium facilitates myocardial relaxation via a cGMP-dependent reduction in myofilament Ca2+ sensitivity. Recent evidence suggests that NO released by a neuronal NO synthase (nNOS) in the myocardium can also hasten left ventricular relaxation; however, the mechanism underlying these findings is uncertain. Here we show that both relaxation (TR50) and the rate of [Ca2+]i transient decay (tau) are significantly prolonged in field-sti...

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Authors: Zhang, Y; Zhang, M; Sears, C; Emanuel, K; Redwood, C

• Publication status: Published
• Journal: Circulation research
• Volume: 102
• Issue: 2
• Pages: 242-249
• Publication date: 2008-02-01
• DOI: 10.1161/circresaha.107.164798
• EISSN: 1524-4571
• ISSN: 0009-7330
• Language: English
• Keywords: Cyclic AMP-Dependent Protein Kinases; Muscle Cells; Mice; Phosphorylation; Cyclic GMP; Heart Ventricles; Animals; Mice, Knockout; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Calcium-Binding Proteins; Myocardial Contraction; Nitric Oxide Synthase Type I