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Small heat-shock proteins: paramedics of the cell.

Abstract:

The small heat-shock proteins (sHSPs) comprise a family of molecular chaperones which are widespread but poorly understood. Despite considerable effort, comparatively few high-resolution structures have been determined for the sHSPs, a likely consequence of their tendency to populate ensembles of inter-converting conformational and oligomeric states at equilibrium. This dynamic structure appears to underpin the sHSPs' ability to bind and sequester target proteins rapidly, and renders them the...

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Publisher copy:
10.1007/128_2012_324

Authors


Journal:
Topics in current chemistry
Volume:
328
Pages:
69-98
Publication date:
2013-01-01
DOI:
EISSN:
1436-5049
ISSN:
0340-1022
URN:
uuid:846a1757-2416-4a70-8e68-789847367632
Source identifiers:
329170
Local pid:
pubs:329170

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