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Thesis

Interaction of anaesthetics with the carotid body glomus cell and the background potassium channel response to hypoxia

Abstract:

This thesis investigates the role anaesthetics play in the depression of the acute hypoxic and hypercapnic ventilatory response. Particular attention is paid to TASK (TWIK related acid sensitive potassium) channels that are known to be sensitive to both hypoxia and the volatile anaesthetics.

After chapters relating to a general introduction and methods, chapter 3 describes studies into the hypoxic and hypercapnic responses of mice with genetic ablation of TASK 1 and/or TASK 3. By us...

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Department:
Trinity College, Oxford
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Department:
Nuffield Department of Anaesthetics
Role:
Supervisor, Author
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Department:
Department of Physiology, Anatomy and Genetics
Role:
Supervisor, Author
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Department:
Department of Physiology, Anatomy and Genetics
Role:
Author, Examiner
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Department:
University of Birmingham
Role:
Author, Examiner
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Grant:
MR/J011452/1
Funding agency for:
Peadar O'Donohoe
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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