Journal article : Review
The omics strategy: the use of systems vaccinology to characterize immune responses to childhood immunization
- Abstract:
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Introduction
Vaccines have had a transformative impact on child health. Despite this impact, the immunological processes involved in protective responses are not entirely understood and vaccine development has been largely empirical. Recent technological advances offer the opportunity to reveal the immunology underlying vaccine response at an unprecedented resolution. These data could revolutionize the way vaccines are developed and tested and further augment their role in securing the health of children around the world.
Areas covered
Systems level information and tools are now being deployed by vaccinologists at all stages of the vaccine development pathway; however, this review will specifically describe some of the key findings that have be gleaned from multi-omics datasets collected in the context of childhood immunization.
Expert opinion
Despite the success of vaccines, there remains hard-to-target pathogens, refractory to current vaccination strategies. Moreover, zoonotic diseases with pandemic potential are a threat to global health, as recently illustrated by COVID-19. Systems vaccinology holds a great deal of promise in revealing a greater understanding of vaccine responses and consequently modernizing vaccinology. However, there is a need for future studies – particularly in vulnerable populations that are targets for vaccination programmes – if this potential is to be fulfilled.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
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- Files:
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(Preview, Version of record, pdf, 762.0KB, Terms of use)
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- Publisher copy:
- 10.1080/14760584.2022.2093193
Authors
- Publisher:
- Taylor and Francis
- Journal:
- Expert Review of Vaccines More from this journal
- Volume:
- 21
- Issue:
- 9
- Pages:
- 1205-1214
- Publication date:
- 2022-07-05
- Acceptance date:
- 2022-06-20
- DOI:
- EISSN:
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1744-8395
- ISSN:
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1476-0584
- Pmid:
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35786291
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1267886
- Local pid:
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pubs:1267886
- Deposit date:
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2023-01-13
Terms of use
- Copyright holder:
- Daniel O’Connor
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
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