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Thesis

Computational studies of structural motifs and cotranslational folding mechanisms in membrane and soluble proteins

Abstract:

Membrane proteins are an important class of drug targets, making up at least 25% of proteins in the human genome. In this thesis I investigated two aspects of alpha-helical membrane protein structures.

Firstly, I investigated kinks in alpha-helices, many of which are thought to have functional roles. Kinks are changes of direction in helices, often defined in a binary fashion, but here I move towards defining them on a continuum. I found that kink angles are not generally...

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Department:
Department of Statistics, University of Oxford
Role:
Copyright Holder, Author

Contributors

Department:
Department of Biochemistry, University of Oxford
Role:
Examiner
Department:
Department of Chemistry, Pennsylvania State University
Role:
Examiner
Department:
Department of Statistics, University of Oxford
Role:
Supervisor
Department:
UCB
Role:
Supervisor
Department:
UCB
Role:
Supervisor
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Grant:
EP/G037280/1
Funding agency for:
Eleanor C Law
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Funding agency for:
Eleanor C Law
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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