Journal article
Rapid stereoselective syntheses of heteroarene-fused azacycles via diastereoselective conjugate addition of heteroaryl substituted lithium amides
- Abstract:
- Conjugate addition of heteroaryl substituted lithium amides to a range of α,β-unsaturated esters followed by in situ enolate oxidation with (–)-(camphorsulfonyl)oxaziridine gave the corresponding α-hydroxy-β-amino esters. Subsequent Friedel-Crafts type cyclisation of these α-hydroxy-β-amino esters gave a range of heteroarene-fused azacycles in good yields and high diastereoselectivities.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 294.6KB, Terms of use)
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- Publisher copy:
- 10.3987/COM-18-S(F)59
Authors
- Publisher:
- Japan Institute of Heterocyclic Chemistry
- Journal:
- Heterocycles More from this journal
- Volume:
- 99
- Issue:
- 2
- Pages:
- 919-941
- Publication date:
- 2018-12-05
- DOI:
- EISSN:
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1881-0942
- ISSN:
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0385-5414
- Pubs id:
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pubs:1039667
- UUID:
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uuid:843bf7cb-31f1-4dcf-b0a0-784f29fc66a0
- Local pid:
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pubs:1039667
- Source identifiers:
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1039667
- Deposit date:
-
2019-08-10
Terms of use
- Copyright holder:
- Japan Institute of Heterocyclic Chemistry
- Copyright date:
- 2018
- Notes:
- Copyright © 2019 The Japan Institute of Heterocyclic Chemistry. This is the accepted manuscript version of the article. The final version is available online from Japan Institute of Heterocyclic Chemistry at: https://doi.org/10.3987/COM-18-S(F)59
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