Bullous pemphigoid and autoimmunity.

Journal article

BACKGROUND: There are many case reports of bullous pemphigoid (BP) in association with a variety of autoimmune disorders, but no large case controlled studies have been performed. OBJECTIVE: Our purpose was to determine whether there is an increased incidence of autoimmune disorders in patients with BP and whether there is a particular haplotype associated with this. METHODS: A total of 108 patients with BP were studied and compared with a group of 108 age- and sex-matched controls. HLA typing at the A, B, C, and DR loci was performed on 55 of the 108 patients with BP. RESULTS: The difference in incidence of autoimmune disorders between patients and controls was not significant. The haplotypes of patients with BP were similar to those of a locally drawn population. CONCLUSION: There is no increase in the incidence of autoimmune disorders in BP, and no particular haplotype appears to be associated with a predisposition to this condition.

Authors: Taylor, G; Venning, V; Wojnarowska, F; Welch, K

• Publication status: Published
• Journal: Journal of the American Academy of Dermatology
• Volume: 29
• Issue: 2 Pt 1
• Pages: 181-184
• Publication date: 1993-08-01
• DOI: 10.1016/0190-9622(93)70164-O
• EISSN: 1097-6787
• ISSN: 0190-9622
• Language: English
• Keywords: Middle Aged; Diabetes Complications; Aged; Aged, 80 and over; HLA Antigens; Male; Female; Incidence; Arthritis, Rheumatoid; Follow-Up Studies; Humans; Pemphigoid, Bullous; Autoimmune Diseases