Clinical studies : an overview.
Disease caused by Neisseria meningitidis is a worldwide problem (1). Epi- demics of meningococcal disease regularly occur in the "meningitis belt" of sub-Saharan Africa and in Asia (2-5) and high or increasing levels of endemic meningococcal disease have been reported recently in the UK (6), New Zealand (7), Cuba (8), Brazil (9), Norway (10), and the Pacific Northwest of the United States (11). Meningococcal disease predominantly affects children and has a high mortality, which has remained u...Expand abstract
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