- Abstract:
-
HspB8, a small heat-shock protein implicated in autophagy, is mutated in patients with distal hereditary motor neuropathy type II (dHMNII). Autophagy is essential for maintaining protein homeostasis in the central nervous system, but its role has not been investigated in peripheral motor neurons. We used a novel, multispectral-imaging flow cytometry assay to measure autophagy in cells. This assay revealed that over-expression of wild-type HspB8 in motor neuron-like NSC34 cells led to an incre...
Expand abstract - Publisher copy:
- 10.1111/j.1471-4159.2011.07521.x
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- Journal:
- Journal of Neurochemistry
- Volume:
- 119
- Issue:
- 6
- Pages:
- 1155-1161
- Publication date:
- 2011-12-05
- DOI:
- EISSN:
-
1471-4159
- ISSN:
-
0022-3042
- URN:
-
uuid:841434cb-2020-4218-bb7a-149539f32cc9
- Source identifiers:
-
221591
- Local pid:
- pubs:221591
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
HspB8 mutation causing hereditary distal motor neuropathy impairs lysosomal delivery of autophagosomes
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