Journal article icon

Journal article

Mathematical modeling of monoclonal conversion in the colonic crypt.

Abstract:

A novel spatial multiscale model of a colonic crypt is described, which couples the cell cycle (including cell division) with the mechanics of cell movement. The model is used to investigate the process of monoclonal conversion under two hypotheses concerning stem cell behavior. Under the first hypothesis, 'stem-ness' is an intrinsic cell property, and the stem cell population is maintained through asymmetric division. Under the second hypothesis, the proliferative behavior of each cell is go...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jtbi.2012.01.021

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of theoretical biology
Volume:
300
Pages:
118-133
Publication date:
2012-05-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:840aee75-f0b4-4b71-8467-4425c7c73e6c
Source identifiers:
245878
Local pid:
pubs:245878

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP