Journal article icon

Journal article

The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes.

Abstract:

Commitment to the melanocyte lineage is characterized by the onset of microphthalmia-associated transcription factor (Mitf) expression. Mitf plays a fundamental role in melanocyte development, with mice lacking Mitf being entirely devoid of pigment cells. In the absence of functional Mitf protein, melanoblasts expressing Mitf mRNA disappear around 2 days after their first appearance either by apoptosis or by losing their identity and adopting an alternative cell fate. The role of Mitf must th...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m000035200

Authors


Carreira, S More by this author
Goding, CR More by this author
Journal:
The Journal of biological chemistry
Volume:
275
Issue:
29
Pages:
21920-21927
Publication date:
2000-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:83dd98d1-d5f2-4087-bf63-fb6e3da3ad0a
Source identifiers:
92910
Local pid:
pubs:92910

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP