- Abstract:
-
Commitment to the melanocyte lineage is characterized by the onset of microphthalmia-associated transcription factor (Mitf) expression. Mitf plays a fundamental role in melanocyte development, with mice lacking Mitf being entirely devoid of pigment cells. In the absence of functional Mitf protein, melanoblasts expressing Mitf mRNA disappear around 2 days after their first appearance either by apoptosis or by losing their identity and adopting an alternative cell fate. The role of Mitf must th...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m000035200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 275
- Issue:
- 29
- Pages:
- 21920-21927
- Publication date:
- 2000-07-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:83dd98d1-d5f2-4087-bf63-fb6e3da3ad0a
- Source identifiers:
-
92910
- Local pid:
- pubs:92910
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes.
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