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SARS-CoV-2 within-host diversity and transmission

Abstract:

Extensive global sampling and sequencing of the pandemic virus SARS-CoV-2 have enabled researchers to monitor its spread, and to identify concerning new variants. Two important determinants of variant spread are how frequently they arise within individuals, and how likely they are to be transmitted. To characterize within-host diversity and transmission we deep-sequenced 1313 clinical samples from the UK. SARS-CoV-2 infections are characterized by low levels of within-host diversity when vira...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.abg0821

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
ORCID:
0000-0002-7089-7680
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0002-9847-1526
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author

Contributors

Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
372
Issue:
6539
Article number:
eabg0821
Publication date:
2020-03-09
Acceptance date:
2021-03-03
DOI:
Language:
English
Keywords:
Pubs id:
1109001
Local pid:
pubs:1109001
Deposit date:
2021-04-10

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