Do liberal thresholds for red cell transfusion result in improved quality of life for patients undergoing intensive chemotherapy for acute myeloid leukemia? A randomized crossover feasibility study

Journal article

Do liberal thresholds for red cell transfusion result in improved quality of life for patients undergoing intensive chemotherapy for acute myeloid leukemia? A randomized crossover feasibility study Hemoglobin (g/L) 82 (77-92) 80 (74-94) 81 (75-94) Platelets (x10 9 /L) 55 (25-112) 75 (26-154) 55 (25-139) White cell count (x10 9 /L) 5 (2-23) 2 (1-14) 2 (1-20) Total RBC units in 8 weeks prior to randomisation 2 (1-2) 1 (0-2) 1 (0-2) Received RBC transfusion prior to randomisation, n (%) 9 (43) 7 (32) 16 (37) ECOG: Eastern Cooperative Oncology Group Performance Status; RBC: red blood cells; q1-q3= quartile 1 to quartile 3; AML: acute myeloid leukemia.

Authors: Morton, S; Sekhar, M; Smethurst, H; Mora, A; Hodge, RL

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Ferrata Storti Foundation
• Journal: Haematologica
• Volume: 107
• Issue: 6
• Pages: 1474-1478
• Publication date: 2022-02-24
• DOI: 10.3324/haematol.2021.279867
• EISSN: 1592-8721
• ISSN: 0390-6078
• Language: English
• Keywords: Medicine; Intensive care medicine; Crossover study; Oncology; Alternative medicine; Chemotherapy; Myeloid leukemia; Pathology; Randomized controlled trial; Crossover; Internal medicine; Quality of life (healthcare)