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Cell-dissociated haemophilus influenzae and bacteria-associated inflammatory mediators in the airways of patients with chronic obstructive pulmonary disease

Abstract:
Patients with COPD have a susceptibility to respiratory tract infections associated with increased pulmonary inflammation. Bacteria can reside within the host as cell-associated (attached to host cells via adhesins, pili or biofilm formation) or cell-dissociated bacteria. It is unclear how bacteria-to-cell interactions affect pulmonary inflammation and whether these levels differ over an exacerbation time course. We sought to investigate the effects of Haemophilius influenzae cell-interaction upon airway inflammation and whether the levels of H. influenzae bacteria and cell-dissociated bacteria differ over an exacerbation time course.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/thoraxjnl-2017-210983.122

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Divisional Administration
Sub department:
MSD Office
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author


Publisher:
BMJ Publishing Group
Host title:
Thorax
Journal:
British Thoracic Society Winter Meeting 2017 More from this journal
Volume:
72
Issue:
Suppl 3
Pages:
A70-A71
Publication date:
2017-11-15
Acceptance date:
2017-09-01
DOI:
EISSN:
1468-3296
ISSN:
0040-6376


Pubs id:
pubs:855776
UUID:
uuid:8383c1f9-6888-4552-972e-56ff167ddd27
Local pid:
pubs:855776
Source identifiers:
855776
Deposit date:
2018-10-04

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