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Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart

Abstract:

AMP-activated protein kinase (AMPK), the key sensor and regulator of cellular energy status, is a heterotrimeric enzyme with multiple isoforms for each subunit (α1/α 2; β1/β2; γ1/γ2/γ3). Mutations in PRKAG2, which encodes the γ2 regulatory subunit, cause a cardiomyopathy characterized by hypertrophy and conduction abnormalities. The two reported PRKAG2 transcript variants, γ2-short and γ2-long (encoding 328 and 569 amino acids respectively), are both widely expressed in adult tissues. We show...

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Publisher copy:
10.1016/j.yjmcc.2012.05.017

Authors


Grignani, RT More by this author
Watkins, H More by this author
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Journal:
Journal of Molecular and Cellular Cardiology
Volume:
53
Issue:
3
Pages:
342-349
Publication date:
2012-09-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:836f99ec-e77f-4ee9-9f16-2b1ba8634caf
Source identifiers:
348881
Local pid:
pubs:348881

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