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Targeted activation of cholinergic interneurons accounts for the modulation of dopamine by striatal nicotinic receptors

Abstract:

Striatal dopamine (DA) is a major player in action selection and reinforcement. DA release is under strong local control by striatal ACh acting at axonal nicotinic ACh receptors (nAChRs) on DA axons. Striatal nAChRs have been shown to control how DA is released in response to ascending activity from DA neurons, and they also directly drive DA release following synchronized activity in a small local cholinergic network. The source of striatal ACh has been thought to arise solely from intrinsic...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1523/ENEURO.0397-17.2018

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Kosillo, P More by this author
Mena-Segovia, J More by this author
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Publisher:
Society for Neuroscience Publisher's website
Journal:
eNeuro Journal website
Volume:
5
Issue:
5
Pages:
Article: e0397
Publication date:
2018-10-12
Acceptance date:
2018-09-16
DOI:
EISSN:
2373-2822
Pubs id:
pubs:924532
URN:
uri:836a3380-7a54-4e5e-9736-83aa86ea47b1
UUID:
uuid:836a3380-7a54-4e5e-9736-83aa86ea47b1
Local pid:
pubs:924532

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