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Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

Abstract:

Protein-protein interactions are essential for the control of cellular functions and are critical for regulation of the immune system. One example is the binding of Fc regions of IgG to the Fc gamma receptors (FcγRs). High sequence identity (98%) between the genes encoding FcγRIIIa (expressed on macrophages and natural killer cells) and FcγRIIIb (expressed on neutrophils) has prevented the development of monospecific agents against these therapeutic targets. We now report the identification o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1073/pnas.1707856115

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Role:
Author
ORCID:
0000-0001-5425-7520
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Role:
Author
ORCID:
0000-0003-4134-7484
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Ann Wilks Memorial Fund More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
115
Issue:
1
Pages:
E72–E81
Publication date:
2017-12-15
Acceptance date:
2017-11-17
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:812801
URN:
uri:8369166f-855a-4bce-b774-89e65267d731
UUID:
uuid:8369166f-855a-4bce-b774-89e65267d731
Local pid:
pubs:812801
Paper number:
1

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