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H₂-driven cofactor regeneration with NAD(P)⁺-reducing hydrogenases.

Abstract:

A large number of industrially relevant enzymes depend upon nicotinamide cofactors, which are too expensive to be added in stoichiometric amounts. Existing NAD(P)H-recycling systems suffer from low activity, or the generation of side products. H₂-driven cofactor regeneration has the advantage of 100% atom efficiency and the use of H₂ as a cheap reducing agent, in a world where sustainable energy carriers are increasingly attractive. The state of development of H₂-driven cofactor-recycling sys...

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Publication status:
Published

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Publisher copy:
10.1111/febs.12245

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Role:
Author
Journal:
The FEBS journal
Volume:
280
Issue:
13
Pages:
3058-3068
Publication date:
2013-07-05
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
URN:
uuid:8334fdb8-bcc3-4f24-ba61-76d453c339ce
Source identifiers:
390823
Local pid:
pubs:390823

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