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Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer.

Abstract:

Prostate tumor growth initially depends on androgens, which act via the androgen receptor (AR). Despite androgen ablation therapy, tumors eventually progress to a castrate-resistant stage in which the AR remains active. The mechanisms are poorly understood but it may be that changes in levels or activity of AR coregulators affect trafficking and activation of the receptor. A key stage in AR signaling occurs in the cytoplasm, where unliganded receptor is associated with the heat shock protein ...

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Publisher copy:
10.1210/me.2012-1056

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Journal:
Molecular endocrinology (Baltimore, Md.)
Volume:
26
Issue:
10
Pages:
1694-1706
Publication date:
2012-10-05
DOI:
EISSN:
1944-9917
ISSN:
0888-8809
URN:
uuid:83329294-44df-4e7d-ac25-20ddc004d3e6
Source identifiers:
349883
Local pid:
pubs:349883

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