Journal article
Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia
- Abstract:
-
CONTEXT: The classic androgen synthesis pathway proceeds via DHEA, androstenedione and testosterone to 5α-dihydrotestosterone (DHT). However, DHT synthesis can also be achieved by an alternative pathway originating from 17α-hydroxyprogesterone (17OHP), which accumulates in congenital adrenal hyperplasia (CAH). Similarly, recent work has highlighted androstenedione-derived 11-oxygenated 19-carbon steroids as active androgens and, in CAH, androstenedione is generated directly from 17OHP. The...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Newton Fund of the Royal Society
More from this funder
Funding agency for:
Storbeck, K
Arlt, W
Grant:
NI150069
281654
+ European Commission
More from this funder
Funding agency for:
Whitaker, M
Tomlinson, J
Ross, R
Arlt, W
Grant:
281654
281654
281654
281654
Bibliographic Details
- Publisher:
- Endocrine Society Publisher's website
- Journal:
- Journal of Clinical Endocrinology and Metabolism Journal website
- Pages:
- 1-26
- Publication date:
- 2016-11-15
- Acceptance date:
- 2016-11-11
- DOI:
- EISSN:
-
1945-7197
- ISSN:
-
0021-972X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:660377
- UUID:
-
uuid:8331b475-e53c-4127-9565-61d66f47a851
- Local pid:
- pubs:660377
- Source identifiers:
-
660377
- Deposit date:
- 2016-11-23
Terms of use
- Copyright holder:
- © 2016 The Journal of Clinical Endocrinology & Metabolism
- Copyright date:
- 2016
- Notes:
- © 2016 The Journal of Clinical Endocrinology & Metabolism. This is the author accepted manuscript following peer review version of the article. The final version is available online from The Journal of Clinical Endocrinology & Metabolism at: 10.1210/jc.2016-2855
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